Rev is a HIV gene.[1][2] The name rev stands for "Regulator of Virion Expression".
The gene's protein product allows fragments of HIV mRNA that contain a Rev Response Element (RRE) to be exported from the nucleus to the cytoplasm.
In the absence of the rev gene, the host RNA splicing machinery in the nucleus quickly splices the RNA so that only the regulatory proteins Rev and Tat and the accessory protein Nef can be produced. In the presence of rev, RNA is exported from the nucleus before it can be spliced, so that the structural proteins and RNA genome can be produced. This mechanism allows a positive feedback loop to allow HIV to overwhelm the host's defenses, and provides time-dependent regulation of replication.[3]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||